Recurrent Miscarriage and Male Factor

How Does the Male Side Cause Recurrent Miscarriage?

Everyone blames the woman. Doctors too. She gets poked and scanned and tested ten different ways while his sperm gets a free pass, and that’s exactly where most clinics are getting it wrong.

• DNA fragmentation: His sperm can fertilize your egg no problem but if the DNA inside is shattered the embryo falls apart within weeks, and an Imperial College London study proved men in recurrent miscarriage couples carry way more sperm DNA damage than guys whose partners never lost a pregnancy.
• Chromosomal stuff: About 3 percent of recurrent loss couples have a balanced translocation in the man’s karyotype which means his sperm keeps delivering unbalanced genetic material and every pregnancy is basically rolling loaded dice that keep coming up wrong.
• Oxidative stress: Smoking, obesity, infections, pollution, all of it floods his sperm with reactive oxygen species that break the DNA apart, and unlike other cells in the body sperm can’t repair their own damage so whatever got wrecked during production stays wrecked forever.
• Low testosterone: A 2019 study flagged reduced testicular steroidogenesis as a specific marker for recurrent miscarriage in male partners, meaning his hormones are producing sperm that can technically do the job but can’t actually hold a pregnancy together past the first trimester.

Half of all recurrent miscarriages have zero identified maternal cause, and that gap is exactly where male factor testing belongs, so couples working with a specialist for IVF treatment in India should be demanding his workup from the very first appointment not after loss number four.

What Tests and Treatments Actually Make a Difference?

A normal semen analysis means absolutely nothing here. Count is fine. Motility is fine. And the pregnancies still keep ending. The problem lives deeper than what that basic report can see.

• DNA fragmentation test: TUNEL or SCD assay, this is the one test that actually matters and almost nobody orders it until way too late, because a man can have textbook semen numbers and still carry sperm with DNA so broken it can’t hold a pregnancy past six weeks.
• Karyotype blood test: Checks for balanced translocations in the man, the American Urologic Association says every male partner in a recurrent loss couple should get this done, and yet most clinics still skip it which is genuinely baffling for a test that costs almost nothing and takes one blood draw.
• Antioxidants: Vitamins C and E, zinc, selenium, CoQ10, taken for two to three months can measurably drop DNA fragmentation levels, and UK researchers at Tommy’s are running trials right now showing this might be one of the cheapest ways to reduce miscarriage risk from male factor.
• IVF with ICSI plus PGT-A: When fragmentation is high or translocations exist, ICSI treatment paired with genetic screening picks only chromosomally normal embryos for transfer, which directly attacks the root cause instead of just crossing fingers and hoping the next one sticks.

The best IVF specialist in India won’t keep handing you progesterone and bed rest without checking his side first. If yours has done that three times running you already know what needs to change here.

Why Consult Dr. Manisha Mehta?

Dr. Manisha Mehta has been doing this for over 20 years. 85% IVF success rate across the hard cases. Repeated failures. Low AMH. Male factor. Uterine problems. She’s worked through all of it, and she still takes the time to go through every failed cycle report before suggesting the next step. Patients come in from across the country after being told there’s nothing left to try. A good number of them are parents now. That only happens when someone actually investigates, rather than running another round and hoping something different happens.

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